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polyclonal antibodies against rad21  (Bethyl)


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    Bethyl polyclonal antibodies against rad21
    A <t>RAD21</t> enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .
    Polyclonal Antibodies Against Rad21, supplied by Bethyl, used in various techniques. Bioz Stars score: 93/100, based on 66 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/polyclonal antibodies against rad21/product/Bethyl
    Average 93 stars, based on 66 article reviews
    polyclonal antibodies against rad21 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression"

    Article Title: A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression

    Journal: PLoS Genetics

    doi: 10.1371/journal.pgen.1009435

    A RAD21 enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .
    Figure Legend Snippet: A RAD21 enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .

    Techniques Used: ChIP-sequencing, Clone Assay, Western Blot



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    A <t>RAD21</t> enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .
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    Image Search Results


    A RAD21 enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .

    Journal: PLoS Genetics

    Article Title: A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression

    doi: 10.1371/journal.pgen.1009435

    Figure Lengend Snippet: A RAD21 enrichment measured by ChIP-seq at the HoxA locus in wildtype and R586W cl1 and cl2. B Heatmap representation of RAD21 and CTCF enrichment, with k-means clustering. Rows are ranked in descending order based on WT RAD21 signal (column 1). C Average signal plots depicting RAD21 enrichment at CTCF sites, a merged list of K27ac peaks (enhancers), and a merged list of K4me3-marked TSSs (promoters) in wildtype and R586W cl1 and cl2. D Overlap of called peaks in wildtype and R586W cl1 and cl2. E Distribution of RAD21 peaks across the given genomic sites in wildtype and R586W mESCs. F Distribution of RAD21 peaks common to both R586W clones but not wildtype mESCs. G Differential analysis using Diffbind of RAD21 signal at peaks common to wildtype and both R586W clones. Red, p-adj<0.1. H Distribution across given genomic sites of peaks with increased or decreased signal in R586W mESCs as measured by Diffbind. For analyses shown, data from 2 biological replicates for each of wildtype, R586W cl1, and R586W cl2 were merged. I Representative western blots showing the levels of indicated proteins in soluble (Sol.) and chromatin-bound (CB) fractions. J Amounts of chromatin-bound protein expressed as a fraction of total (chromatin-bound + soluble) signal for WT, R586W cl1, and R586W cl2. n = 3 biological replicates. All differences not significant as measured by two-way ANOVA. Numerical data are presented in .

    Article Snippet: For ChIP, polyclonal antibodies against RAD21 (Bethyl Laboratories, A300-080A), H3K4me3 (Abcam, ab8580), H3K27ac (Active Motif, Carlsbad, CA; 39135), H3K27me3 (Abcam, ab6002) were used.

    Techniques: ChIP-sequencing, Clone Assay, Western Blot